Keep an eye on Intently (one)mitotane decreases levels of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Mitotane is a solid inducer of cytochrome P-4503A4; keep an eye on when coadministered with CYP3A4 substrates for attainable dosage adjustments.
This is a lot more more likely to come about from initiation of elranatamab move-up dosing as much as 14 times after the initial treatment dose and during and following CRS.
ergotamine, bromocriptine. Possibly increases toxicity of the opposite by pharmacodynamic synergism. Stay away from or Use Alternate Drug. The concomitant utilization of bromocriptine with ergot alkaloids could probably cause ergot toxicity; consequently The mix must be avoided.
procarbazine raises effects of caffeine by pharmacodynamic synergism. Contraindicated. Caffeine can generate extreme hypertensive crises or unsafe cardiac arrhythmias if administered to people taking a MAOI. All preparations that contains caffeine need to be utilised sparingly.
fosamprenavir will enhance the amount or influence of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
Coadministration with CYP3A4 substrates, specifically These with a narrow therapeutic index, can lead to decreased concentrations and lack of efficacy. If not able to stay away from coadministration, check CYP3A4 substrate ranges and regulate dose as necessary.
Observe Carefully (one)trofinetide will enhance the amount or result of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
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levoketoconazole will boost the amount or influence of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
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