Keep an eye on Intently (one)mitotane decreases levels of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Mitotane is a solid inducer of cytochrome P-4503A4; keep an eye on when coadministered with CYP3A4 substrates for attainable dosage adjustments.This is a lot more more likely to come about from in